Hello,
Sebenarnya cukup baik pengupasan nya sdh ada di Wiki sbb:
1. http://en.wikipedia.org/wiki/Skin_whitening
Further, some controversial research has suggested that kojic acid may
have carcinogenic properties in large doses.[15][16] Other further
studies show that kojic acid is not carcinogenic,[17] but can cause
allergic contact dermatitis[18] and skin irritation.[19][20]
2. Restricted by country / gov Hazard:
Government, industry, academic studies and classifications
government/industry list/academic study appears on list as
classification(s)
Canada - Prohibited and Restricted Cosmetics Ingredients GLYCOLIC
ACID Restricted
Canada - Prohibited and Restricted Cosmetics Ingredients RETINOL
Restricted
Cosmetic Ingredient Review Assessments GLYCOLIC ACID
QQQ02,QQQ36,QQQ25,QQQ19,QQQ38 [special case 15,QQQ19,QQQ31]; D+, M-, C-
Cosmetic Ingredient Review Assessments RETINOL QQQ01,QQQ11; R+, M-, C+
National Library of Medicine HazMap GLYCOLIC ACID DE: Skin Burns;
references
government/industry list/academic study reference
Canada - Prohibited and Restricted Cosmetics Ingredients Health Canada.
2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's
Cosmetic Ingredient Hotlist. March 2007.
Cosmetic Ingredient Review Assessments CIR (Cosmetic Ingredient
Review). 2006. CIR Compendium, containing abstracts, discussions, and
conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
National Library of Medicine HazMap NLM (National Library of Medicine).
2006. HazMap — Occupational Exposure to Hazardous Agents.
3. Toxid:
Other RTECS® classifications [shown for informational purposes only]
government/industry list/academic study appears on list as
classification(s)
RTECS^® - "Antibiotics: Origin, Nature, and Properties," Korzyoski, T
1978 KOJIC ACID • broad systemic - Broad systemic toxicity (rat LDLo)
RTECS^® - "CRC Handbook of Antibiotic Compounds," Vols 1981 KOJIC
ACID • broad systemic - Broad systemic toxicity (mouse LD50)
RTECS^® - Food and Chemical Toxicology 2004 KOJIC ACID • mutagenic -
Positive mutation assay: Mutation in Micro-organism (Salmonella
typhimurium )
• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster lvr)
• mutagenic - Positive mutation assay: Micronucleus test ( human lvr)
RTECS^® - Food and Chemical Toxicology 2004 KOJIC ACID • brain,
nervous system, or behavioral effect - Ataxia (rat TDLo)
• kidney or renal system - Changes in kidney weight (rat TDLo)
• blood - Changes in leucocyte (WBC) count (rat TDLo)
• liver - Changes in liver weight (rat TDLo)
• liver - Fatty liver degeneration (rat TDLo)
• brain, nervous system, or behavioral effect - Muscle contraction or
spasticity (rat TDLo)
• mutagenic - Positive mutation assay: Mutation in Micro-organism
(Salmonella typhimurium )
• mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster lvr)
• mutagenic - Positive mutation assay: Micronucleus test ( human lvr)
RTECS^® - Journal of Toxicological Sciences 1997 KOJIC ACID • cancer -
endocrine system tumor formations - equivocal (rat TDLo)
RTECS^® - Journal of Toxicological Sciences 2000 KOJIC ACID •
metabolic - Weight loss or decreased weight gain (rat TDLo)
• brain, nervous system, or behavioral effect - Changes in motor
activity (specific assay) (rat TDLo)
• endocrine system - Changes in thyroid weight (rat TDLo)
• endocrine system - Evidence of thyroid hypofunction (rat TDLo)
• brain, nervous system, or behavioral effect - Food intake (animal)
(rat TDLo)
• endocrine system - Other changes (rat TDLo)
• brain, nervous system, or behavioral effect - Somnolence (general
depressed activity) (rat TDLo)
RTECS^® - Journal of Toxicological Sciences 2001 KOJIC ACID •
endocrine system - Changes in thyroid weight (rat TDLo)
• endocrine system - Other changes (rat TDLo)
RTECS^® - Journal of Toxicological Sciences 2002 KOJIC ACID •
endocrine system - Evidence of thyroid hypofunction (rat TDLo)
• brain, nervous system, or behavioral effect - Somnolence (general
depressed activity) (rat TDLo)
RTECS^® - Mutation Research 1978 KOJIC ACID • mutagenic - Positive
mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS^® - Mutation Research 2005 KOJIC ACID • mutagenic - Positive
mutation assay: Micronucleus test (rat orl)
RTECS^® - Mutation Research 1979 KOJIC ACID • mutagenic - Positive
mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS^® - Mutation Research 1978 KOJIC ACID • mutagenic - Positive
mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS^® - Mutation Research 2005 KOJIC ACID • mutagenic - Positive
mutation assay: Micronucleus test (rat orl)
RTECS^® - Mutation Research 1979 KOJIC ACID • mutagenic - Positive
mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
RTECS^® - Nature 1945 KOJIC ACID • brain, nervous system, or
behavioral effect - Convulsions or effect on seizure threshold (mouse LDLo)
• respiratory - Respiratory depression (mouse LDLo)
• brain, nervous system, or behavioral effect - Somnolence (general
depressed activity) (mouse LDLo)
RTECS^® - Poultry Science 1991 KOJIC ACID • gastrointestinal - Changes
in pancreatic weight (chicken TDLo)
• cardiovascular - Shock (chicken TDLo)
• brain, nervous system, or behavioral effect - Somnolence (general
depressed activity) (chicken TDLo)
RTECS^® - Toxicological Sciences (Oxford University Press, 6277 Sea
Harbor Drive, Orlando, FL 32887 ) V 2003 KOJIC ACID • cancer -
Increased incidence of tumors in susceptible strains (mouse TDLo)
• cancer - liver tumors (mouse TDLo)
RTECS^® - Toxicologist 2006 KOJIC ACID • cancer - endocrine system
tumors (rat TDLo)
• cancer - Facilitates action of known carcinogen (rat TDLo)
RTECS^® - Toxicology Letters 1991 KOJIC ACID • mutagenic - Positive
mutation assay: Cytogenetic Analysis (hamster ovr)
• mutagenic - Positive mutation assay: Sister Chromatid Exchange
(hamster ovr)
RTECS^® - Toxicology Letters 1991 KOJIC ACID • mutagenic - Positive
mutation assay: Cytogenetic Analysis (hamster ovr)
• mutagenic - Positive mutation assay: Sister Chromatid Exchange
(hamster ovr)
references
government/industry list/academic study reference
Int'l Agency for Research on Cancer (IARC) - Carcinogens IARC
(International Agency for Research on Cancer). 2008. Overall Evaluations
of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes
1-99 (a total of 935 agents, mixtures and exposures).
RTECS^® - "Antibiotics: Origin, Nature, and Properties," Korzyoski, T
1978 [shown for informational purposes only] RTECS^® - "Antibiotics:
Origin, Nature, and Properties," Korzyoski, T., et al., eds.,
Washington, DC, American Soc. for Microbiology, 1978 3,1755,1978
RTECS^® - "CRC Handbook of Antibiotic Compounds," Vols 1981 [shown for
informational purposes only] RTECS^® - "CRC Handbook of Antibiotic
Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980-
5,393,1981
RTECS^® - Food and Chemical Toxicology 2004 [shown for informational
purposes only] RTECS^® - Food and Chemical Toxicology. (Pergamon Press
Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 42,93,2004
RTECS^® - Food and Chemical Toxicology 2004 [shown for informational
purposes only] RTECS^® - Food and Chemical Toxicology. (Pergamon Press
Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
42,93,2004
RTECS^® - Journal of Toxicological Sciences 1997 [shown for
informational purposes only] RTECS^® - Journal of Toxicological
Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
1976- 22,356,1997
RTECS^® - Journal of Toxicological Sciences 2000 [shown for
informational purposes only] RTECS^® - Journal of Toxicological
Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
1976- 25,167,2000
RTECS^® - Journal of Toxicological Sciences 2001 [shown for
informational purposes only] RTECS^® - Journal of Toxicological
Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
1976- 26,85,2001
RTECS^® - Journal of Toxicological Sciences 2002 [shown for
informational purposes only] RTECS^® - Journal of Toxicological
Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
1976- 27,423,2002
RTECS^® - Mutation Research 1978 [shown for informational purposes
only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 58,193,1978
RTECS^® - Mutation Research 2005 [shown for informational purposes
only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 583,133,2005
RTECS^® - Mutation Research 1979 [shown for informational purposes
only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 67,367,1979
RTECS^® - Mutation Research 1978 [shown for informational purposes
only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- -1964 58,193,1978
RTECS^® - Mutation Research 2005 [shown for informational purposes
only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- -1964 583,133,2005
RTECS^® - Mutation Research 1979 [shown for informational purposes
only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- -1964 67,367,1979
RTECS^® - Nature 1945 [shown for informational purposes only] RTECS^® -
Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1-
1869- 155,302,1945
RTECS^® - Poultry Science 1991 [shown for informational purposes only]
RTECS^® - Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark
St., Champaign, IL 61820) V.1- -1921 70,499,1991
RTECS^® - Toxicological Sciences (Oxford University Press, 6277 Sea
Harbor Drive, Orlando, FL 32887 ) V 2003 [shown for informational
purposes only] RTECS^® - Toxicological Sciences (Oxford University
Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
73,287,2003
RTECS^® - Toxicologist 2006 [shown for informational purposes only]
RTECS^® - Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge
Parkway, Akron, OH 44311) V.1- -1981 90,12,2006
RTECS^® - Toxicology Letters 1991 [shown for informational purposes
only] RTECS^® - Toxicology Letters. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 59,213,1991
RTECS^® - Toxicology Letters 1991 [shown for informational purposes
only] RTECS^® - Toxicology Letters. (Elsevier Science Pub. B.V., POB
211, 1000 AE Amsterdam, Netherlands) V.1- 59,213,1991
"RTECS®" is a United States trademark owned and licensed under authority
of the U.S. Government, by and through MDL Information Systems, Inc.
Jadi pertanyaanya adalah:
Anda mo gunakanya buat apa?
Muka?
Mau membuat muka jadi Michael Jackson?
Apakah dg muka spt michael lalu org akan menggab kalau anda itu putih?
Be natural, be happy dg apa yg dianugrahkan Tuhan bagi tubuh anda, iya
kalau pake cream tadi anda jadi putih?
Kalau bengkak? merah n kemudian jadi belang2 hitam? keracunan? Cancer?
Bukan tdk boleh merawat tubuh, tapi motivasi perawatan yg ingin merubah
waran kulit, sangat sering menajdikan ybs menjadi iya berubah tapi bukan
putih melainkan kemerahan n akairnya merah kehitaman, ini yg anda cari?
Adakah obat2an yg anda sebutkan di atur oleh dokter kulit yg mengerti
ttg jenis kulit anda n akan beratanggung jwaba bila alergi terjadi
terhadap bahan2 tersebut? ataukah anda yg cari2 sendiri utk maksud
memutihkannya?
Salam,
On 5/26/2012 9:41 PM, Kikie Syg wrote:
> malem dokter… dok,mau nanya nih,kalo saya pake sabun yg
> terbuat dari kojic acid, boleh ga ya dikombinasiin ama krim malam/siang
> yg mengandung retinol (seperti serum melanox premium), atau dgn krim
> glycore 10(glycolid acid).. takutnya ada interaksi obat satu sama
> lainnya dok.. tolong nasehatnya ya dok, penting bgt nih, urgent dok,
> hehe..makaciiih
>
> [Non-text portions of this message have been removed]
>
>
>
> ------------------------------------
>
--
We care human as human not as sickness object --
"Absolutely Drug less Health Care solution Organization"
[Non-text portions of this message have been removed]
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