> Hai,
> Masalah anda adalah: amankah penggunaan kojic acid bila dikombinasi dengan asam retinoat atau dengan asam glikolid? Well, dari salah satu artikel yg saya baca, pernah dilakukan penelitian antara penggunaan kombinasi kojic acid/asam glicolid dengan hydroquinone/asam glicolid. Penelitian itu menyebutkan kalo kombinasi kojic/glicolid acid lebih menyebabkan iritasi. Meskipun itu cuma sebagian kecil saja yg mengalami efek tersebut.
Konsentrasi kojic acid yg aman digunakan adalah 1-4 %.
Jika anda ingin mengkombinasikan pemakain sabun asam kojic dengan obat topikal /oles lainnya ada baiknya anda konsultasikan dengan dokter kecantikan anda atau dengan dokter spesialis kulit & kelamin.
Trima kasih
-syahrul
On May 29, 2012, at 4:16 PM, "Dr.(Naturopathy) Ir. Donny Hosea MBA. PhD" <puyuh23@indo.net.id> wrote:
> Hello,
> Sebenarnya cukup baik pengupasan nya sdh ada di Wiki sbb:
>
> 1. http://en.wikipedia.org/wiki/Skin_whitening
> Further, some controversial research has suggested that kojic acid may
> have carcinogenic properties in large doses.[15][16] Other further
> studies show that kojic acid is not carcinogenic,[17] but can cause
> allergic contact dermatitis[18] and skin irritation.[19][20]
>
> 2. Restricted by country / gov Hazard:
>
> Government, industry, academic studies and classifications
>
> government/industry list/academic study appears on list as
> classification(s)
> Canada - Prohibited and Restricted Cosmetics Ingredients GLYCOLIC
> ACID Restricted
> Canada - Prohibited and Restricted Cosmetics Ingredients RETINOL
> Restricted
> Cosmetic Ingredient Review Assessments GLYCOLIC ACID
> QQQ02,QQQ36,QQQ25,QQQ19,QQQ38 [special case 15,QQQ19,QQQ31]; D+, M-, C-
> Cosmetic Ingredient Review Assessments RETINOL QQQ01,QQQ11; R+, M-, C+
> National Library of Medicine HazMap GLYCOLIC ACID DE: Skin Burns;
>
> references
>
> government/industry list/academic study reference
> Canada - Prohibited and Restricted Cosmetics Ingredients Health Canada.
> 2007. List of Prohibited and Restricted Cosmetic Ingredients. Canada's
> Cosmetic Ingredient Hotlist. March 2007.
> Cosmetic Ingredient Review Assessments CIR (Cosmetic Ingredient
> Review). 2006. CIR Compendium, containing abstracts, discussions, and
> conclusions of CIR cosmetic ingredient safety assessments. Washington DC.
> National Library of Medicine HazMap NLM (National Library of Medicine).
> 2006. HazMap — Occupational Exposure to Hazardous Agents.
>
> 3. Toxid:
>
> Other RTECS® classifications [shown for informational purposes only]
>
> government/industry list/academic study appears on list as
> classification(s)
> RTECS^® - "Antibiotics: Origin, Nature, and Properties," Korzyoski, T
> 1978 KOJIC ACID • broad systemic - Broad systemic toxicity (rat LDLo)
> RTECS^® - "CRC Handbook of Antibiotic Compounds," Vols 1981 KOJIC
> ACID • broad systemic - Broad systemic toxicity (mouse LD50)
> RTECS^® - Food and Chemical Toxicology 2004 KOJIC ACID • mutagenic -
> Positive mutation assay: Mutation in Micro-organism (Salmonella
> typhimurium )
> • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster lvr)
> • mutagenic - Positive mutation assay: Micronucleus test ( human lvr)
> RTECS^® - Food and Chemical Toxicology 2004 KOJIC ACID • brain,
> nervous system, or behavioral effect - Ataxia (rat TDLo)
> • kidney or renal system - Changes in kidney weight (rat TDLo)
> • blood - Changes in leucocyte (WBC) count (rat TDLo)
> • liver - Changes in liver weight (rat TDLo)
> • liver - Fatty liver degeneration (rat TDLo)
> • brain, nervous system, or behavioral effect - Muscle contraction or
> spasticity (rat TDLo)
> • mutagenic - Positive mutation assay: Mutation in Micro-organism
> (Salmonella typhimurium )
> • mutagenic - Positive mutation assay: Cytogenetic Analysis (hamster lvr)
> • mutagenic - Positive mutation assay: Micronucleus test ( human lvr)
> RTECS^® - Journal of Toxicological Sciences 1997 KOJIC ACID • cancer -
> endocrine system tumor formations - equivocal (rat TDLo)
> RTECS^® - Journal of Toxicological Sciences 2000 KOJIC ACID •
> metabolic - Weight loss or decreased weight gain (rat TDLo)
> • brain, nervous system, or behavioral effect - Changes in motor
> activity (specific assay) (rat TDLo)
> • endocrine system - Changes in thyroid weight (rat TDLo)
> • endocrine system - Evidence of thyroid hypofunction (rat TDLo)
> • brain, nervous system, or behavioral effect - Food intake (animal)
> (rat TDLo)
> • endocrine system - Other changes (rat TDLo)
> • brain, nervous system, or behavioral effect - Somnolence (general
> depressed activity) (rat TDLo)
> RTECS^® - Journal of Toxicological Sciences 2001 KOJIC ACID •
> endocrine system - Changes in thyroid weight (rat TDLo)
> • endocrine system - Other changes (rat TDLo)
> RTECS^® - Journal of Toxicological Sciences 2002 KOJIC ACID •
> endocrine system - Evidence of thyroid hypofunction (rat TDLo)
> • brain, nervous system, or behavioral effect - Somnolence (general
> depressed activity) (rat TDLo)
> RTECS^® - Mutation Research 1978 KOJIC ACID • mutagenic - Positive
> mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
> RTECS^® - Mutation Research 2005 KOJIC ACID • mutagenic - Positive
> mutation assay: Micronucleus test (rat orl)
> RTECS^® - Mutation Research 1979 KOJIC ACID • mutagenic - Positive
> mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
> RTECS^® - Mutation Research 1978 KOJIC ACID • mutagenic - Positive
> mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
> RTECS^® - Mutation Research 2005 KOJIC ACID • mutagenic - Positive
> mutation assay: Micronucleus test (rat orl)
> RTECS^® - Mutation Research 1979 KOJIC ACID • mutagenic - Positive
> mutation assay: Mutation in Micro-organism (Salmonella typhimurium )
> RTECS^® - Nature 1945 KOJIC ACID • brain, nervous system, or
> behavioral effect - Convulsions or effect on seizure threshold (mouse LDLo)
> • respiratory - Respiratory depression (mouse LDLo)
> • brain, nervous system, or behavioral effect - Somnolence (general
> depressed activity) (mouse LDLo)
> RTECS^® - Poultry Science 1991 KOJIC ACID • gastrointestinal - Changes
> in pancreatic weight (chicken TDLo)
> • cardiovascular - Shock (chicken TDLo)
> • brain, nervous system, or behavioral effect - Somnolence (general
> depressed activity) (chicken TDLo)
> RTECS^® - Toxicological Sciences (Oxford University Press, 6277 Sea
> Harbor Drive, Orlando, FL 32887 ) V 2003 KOJIC ACID • cancer -
> Increased incidence of tumors in susceptible strains (mouse TDLo)
> • cancer - liver tumors (mouse TDLo)
> RTECS^® - Toxicologist 2006 KOJIC ACID • cancer - endocrine system
> tumors (rat TDLo)
> • cancer - Facilitates action of known carcinogen (rat TDLo)
> RTECS^® - Toxicology Letters 1991 KOJIC ACID • mutagenic - Positive
> mutation assay: Cytogenetic Analysis (hamster ovr)
> • mutagenic - Positive mutation assay: Sister Chromatid Exchange
> (hamster ovr)
> RTECS^® - Toxicology Letters 1991 KOJIC ACID • mutagenic - Positive
> mutation assay: Cytogenetic Analysis (hamster ovr)
> • mutagenic - Positive mutation assay: Sister Chromatid Exchange
> (hamster ovr)
>
> references
>
> government/industry list/academic study reference
> Int'l Agency for Research on Cancer (IARC) - Carcinogens IARC
> (International Agency for Research on Cancer). 2008. Overall Evaluations
> of Carcinogenicity to Humans, as evaluated in IARC Monographs Volumes
> 1-99 (a total of 935 agents, mixtures and exposures).
> RTECS^® - "Antibiotics: Origin, Nature, and Properties," Korzyoski, T
> 1978 [shown for informational purposes only] RTECS^® - "Antibiotics:
> Origin, Nature, and Properties," Korzyoski, T., et al., eds.,
> Washington, DC, American Soc. for Microbiology, 1978 3,1755,1978
> RTECS^® - "CRC Handbook of Antibiotic Compounds," Vols 1981 [shown for
> informational purposes only] RTECS^® - "CRC Handbook of Antibiotic
> Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980-
> 5,393,1981
> RTECS^® - Food and Chemical Toxicology 2004 [shown for informational
> purposes only] RTECS^® - Food and Chemical Toxicology. (Pergamon Press
> Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 42,93,2004
> RTECS^® - Food and Chemical Toxicology 2004 [shown for informational
> purposes only] RTECS^® - Food and Chemical Toxicology. (Pergamon Press
> Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
> 42,93,2004
> RTECS^® - Journal of Toxicological Sciences 1997 [shown for
> informational purposes only] RTECS^® - Journal of Toxicological
> Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
> Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
> 1976- 22,356,1997
> RTECS^® - Journal of Toxicological Sciences 2000 [shown for
> informational purposes only] RTECS^® - Journal of Toxicological
> Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
> Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
> 1976- 25,167,2000
> RTECS^® - Journal of Toxicological Sciences 2001 [shown for
> informational purposes only] RTECS^® - Journal of Toxicological
> Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
> Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
> 1976- 26,85,2001
> RTECS^® - Journal of Toxicological Sciences 2002 [shown for
> informational purposes only] RTECS^® - Journal of Toxicological
> Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai
> Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1-
> 1976- 27,423,2002
> RTECS^® - Mutation Research 1978 [shown for informational purposes
> only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- 58,193,1978
> RTECS^® - Mutation Research 2005 [shown for informational purposes
> only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- 583,133,2005
> RTECS^® - Mutation Research 1979 [shown for informational purposes
> only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- 67,367,1979
> RTECS^® - Mutation Research 1978 [shown for informational purposes
> only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 58,193,1978
> RTECS^® - Mutation Research 2005 [shown for informational purposes
> only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 583,133,2005
> RTECS^® - Mutation Research 1979 [shown for informational purposes
> only] RTECS^® - Mutation Research. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- -1964 67,367,1979
> RTECS^® - Nature 1945 [shown for informational purposes only] RTECS^® -
> Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1-
> 1869- 155,302,1945
> RTECS^® - Poultry Science 1991 [shown for informational purposes only]
> RTECS^® - Poultry Science. (Poultry Science Assoc., Inc., 309 W. Clark
> St., Champaign, IL 61820) V.1- -1921 70,499,1991
> RTECS^® - Toxicological Sciences (Oxford University Press, 6277 Sea
> Harbor Drive, Orlando, FL 32887 ) V 2003 [shown for informational
> purposes only] RTECS^® - Toxicological Sciences (Oxford University
> Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
> 73,287,2003
> RTECS^® - Toxicologist 2006 [shown for informational purposes only]
> RTECS^® - Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge
> Parkway, Akron, OH 44311) V.1- -1981 90,12,2006
> RTECS^® - Toxicology Letters 1991 [shown for informational purposes
> only] RTECS^® - Toxicology Letters. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- 1977- 59,213,1991
> RTECS^® - Toxicology Letters 1991 [shown for informational purposes
> only] RTECS^® - Toxicology Letters. (Elsevier Science Pub. B.V., POB
> 211, 1000 AE Amsterdam, Netherlands) V.1- 59,213,1991
>
> "RTECS®" is a United States trademark owned and licensed under authority
> of the U.S. Government, by and through MDL Information Systems, Inc.
>
> Jadi pertanyaanya adalah:
> Anda mo gunakanya buat apa?
> Muka?
> Mau membuat muka jadi Michael Jackson?
> Apakah dg muka spt michael lalu org akan menggab kalau anda itu putih?
> Be natural, be happy dg apa yg dianugrahkan Tuhan bagi tubuh anda, iya
> kalau pake cream tadi anda jadi putih?
> Kalau bengkak? merah n kemudian jadi belang2 hitam? keracunan? Cancer?
> Bukan tdk boleh merawat tubuh, tapi motivasi perawatan yg ingin merubah
> waran kulit, sangat sering menajdikan ybs menjadi iya berubah tapi bukan
> putih melainkan kemerahan n akairnya merah kehitaman, ini yg anda cari?
> Adakah obat2an yg anda sebutkan di atur oleh dokter kulit yg mengerti
> ttg jenis kulit anda n akan beratanggung jwaba bila alergi terjadi
> terhadap bahan2 tersebut? ataukah anda yg cari2 sendiri utk maksud
> memutihkannya?
>
> Salam,
>
> On 5/26/2012 9:41 PM, Kikie Syg wrote:
> > malem dokter… dok,mau nanya nih,kalo saya pake sabun yg
> > terbuat dari kojic acid, boleh ga ya dikombinasiin ama krim malam/siang
> > yg mengandung retinol (seperti serum melanox premium), atau dgn krim
> > glycore 10(glycolid acid).. takutnya ada interaksi obat satu sama
> > lainnya dok.. tolong nasehatnya ya dok, penting bgt nih, urgent dok,
> > hehe..makaciiih
> >
> > [Non-text portions of this message have been removed]
> >
> >
> >
> > ------------------------------------
> >
>
> --
> We care human as human not as sickness object --
> "Absolutely Drug less Health Care solution Organization"
>
> [Non-text portions of this message have been removed]
>
>
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