Hello,
cukup jelas hal ini utk dibandingkan dg merujukan pada kupasan di wiki sbb:
http://en.wikipedia.org/wiki/Rheumatoid_arthritis
VS
http://en.wikipedia.org/wiki/Osteoarthritis
Pada kalimat 1 tertera:
Osteoarthritis (OA) also known as
degenerative arthritis or degenerative joint disease
=======================================
or osteoarthrosis, is a group of mechanical abnormalities involving
degradation of joints,[1] including articular cartilage and subchondral
bone.
sedangkan:
Rheumatoid arthritis (RA) is a chronic,
systemic inflammatory disorder that may affect many tissues and organs,
=======================================================
but principally attacks flexible (synovial) joints. The process involves
an inflammatory response of the capsule around the joints (synovium)
secondary to swelling (hyperplasia) of synovial cells, excess synovial
fluid, and the development of fibrous tissue (pannus) in the synovium.
The pathology of the disease process often leads to the destruction of
articular cartilage and ankylosis (fusion) of the joints.
sekarang pertanyaanya:
1. Apa yg dilakukan oleh Glucosamine n Chondroitin?
di: http://www.bmj.com/content/341/bmj.c4675.full
Study selection
We included randomised trials with an average of at least 100 patients
with knee or hip osteoarthritis per arm.18 Trials compared chondroitin
sulphate, glucosamine sulphate, glucosamine hydrochloride, or the
combination of any two with placebo or head to head. A sample size of
2×100 patients will yield more than 80% power to detect a small to
moderate effect size of −0.40 at a two sided P=0.05, which corresponds
to a difference of 1 cm on a 10 cm visual analogue scale between the
experimental and control intervention. Two of four reviewers (BT, EN,
SR, ST) evaluated reports independently for eligibility. They excluded
trial arms with sub-therapeutic doses (<800 mg/day of chondroitin and
<1500 mg/day of glucosamine, in accordance with doses licensed in
Europe). Disagreements were resolved by consensus.
kesimpulan dlm study ini:
What is already known on this topic
Chondroitin and glucosamine have been recommended in guidelines,
prescribed by general practitioners and rheumatologists, and used by
patients as over the counter medications to modify the clinical and
radiological course of osteoarthritis
Results from randomised trials about the effectiveness of chondroitin
and glucosamine are conflicting
What this study adds
Chondroitin, glucosamine, and their combination do not have a clinically
relevant effect on perceived joint pain or on joint space narrowing
Estimated differences between supplements and placebo were less
pronounced on average in industry independent trials, and estimated
treatment effects in industry independent trials were small or absent
and clinically irrelevant
2. masih pertanyaan:
Bagaimana anda menemukan nama, baik disease ataupun bahan Chondroitin
Glocosamine sebagai BOM obat utk memeprbaiki keadaan tanpa mengerti ttg
apa yg terjadi n bagaimana terjadinya?
Persoalannya bukan bisa n tdk bisa tetapi apakah benar membantu, benar
memperbaiki, ataukah benar bermanfaat?
3. Dari mana anda mengetahui dg persis bahwa itu RA n bukan yg lainya?
Pada prinsipnya Chondroitin Glocosamine adalah bahan dg kapasitas yg
cukup asam, jadi apakah RA atau OA terjadi bukan karena keasaman yg
berlebihan pada tubuh sehingga pemberian Chondroitin Glocosamine bisa
bermanfaat?
Jadi meskipun direkomendasikan tetapi amat sangat penting bila mengerti
dg lebih jauh sebelum menggunakan sesuatu bahan.
Salam,
Partial document are Cite from: BMJ 2010;341:c4675 , thanks to BMJ
On 6/29/2012 11:30 AM, Fransisca Titin wrote:
> Dear dokter,
> Sy mau tny ttg pemberian glukosamin & kondroitin utk ayah sy yg menderita reumatoid artritis. Apakah bs? Atau glukosamin & kondroitin hny bisa utk org yg terkena osteoartritis saja? Mohon sarannya.
> Terima kasih
>
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