Hello,
Adalat berisi nifedipine:
Contraindications
Hypersensitivity to nifedipine; arterial hypotension, severe aortic
valve stenosis, obstructive cardiomyopathy, porphyria,
Special Precautions Nifedipine should not be used in cardiogenic shock
and angina pectoris at rest (because it may precipitate myocardial
infarction). It should be used with caution in patients with congestive
heart failure, liver insufficiency and diabetes.
Patients who have severe obstructive coronary disease may develop
(rarely) increased frequency, severity and duration of angina pectoris
attack after ingestion of nifedipine. In this case, nifedipine therapy
should be ceased.
Effects on the Ability to Drive or Operate Machinery: Not known.
Use in pregnancy: There is no adequate evidence on safe use of
nifedipine in pregnant women and the drug should be used during
pregnancy only when the potential benefit justifies the possible risk to
the fetus.
Use in lactation: Nifedipine is excreted in breast milk, therefore, it
should not be prescribed to nursing mothers.
Adverse Drug Reactions The most common side effects reported with
nifedipine include peripheral edema, headache, flushing, heat sensation,
dizziness, fatigue, constipation and nausea. In some instances,
retrosternal pain may occur after ingestion of nifedipine.
Giddiness, lethargy, hypotension, syncope, palpitations, cardiac
decompensation, gingival hyperplasia, cramps in the upper and lower
extremities and diarrhea have been reported.
Drug Interactions
When nifedipine is administered concomitantly with antihypertensive
drugs, β-adrenergic blocking agents and nitrates, their synergistic
activity should be taken into account. Administration of nifedipine with
digoxin may increase digoxin levels, therefore, serum digoxin
concentrations should be monitored and when required, digoxin dose
should be adjusted.
Nifedipine may reduce the metabolism of phenytoin, while concomitant
administration of cyclosporin or cimetidine may cause increased
nifedipine levels. Concomitant administration of nifedipine and fentanyl
may cause severe hypotension, therefore, it is recommended to withhold
nifedipine therapy for at least 36 hrs prior to anesthesia (if
possible). Plasma quinidine concentrations may decrease by 50% in
patients receiving nifedipine and quinidine concomitantly. Nifedipine
increases blood theophylline level during concomitant administration.
Mechanism of Action
Nifedipine is a calcium antagonist. It inhibits the transmembrane influx
of extracellular calcium ions across the membranes of myocardial cells
or vascular smooth muscle cells, without changing blood-calcium
concentrations. As a result of systemic arterial and arteriolar
dilation, nifedipine causes a reduction in peripheral vascular
resistance and; therefore decreases arterial blood pressure. Nifedipine
dilates the main coronary arteries and arterioles, both in normal and
ischemic myocardial regions and is a potent inhibitor of coronary artery
spasm. Nifedipine increases myocardial oxygen delivery, which accounts
for its effectiveness in the treatment of angina pectoris.
Nifedipine is rapidly and nearly completely absorbed. It is in high
percentage bound to plasma proteins. The elimination half-life is
approximately 2 hrs. Most of nifedipine is excreted in the urine.
Nifecard XL, by extended release of the active ingredient, provides a
rise of plasma nifedipine concentrations at a gradual, controlled rate
which reach a plateau at approximately 6 hrs after the first dose. For
subsequent dose, constant plasma concentrations at this plateau are
maintained with minimal fluctuations over the 24-hr dosing period.
Jadi pertanyaanya, apakah herbs yg anda sebut mengacaukan proses
mekanime kerja obat atau tdk?
Belum juga faktor kompatibilitas dg tubuh yg kemeudian mempengaruhi
pembekluan darah dlsbnya.
Salam,
On 2/25/2013 12:21 PM, indo_jkt@yahoo.co.id wrote:
> Dok, sy menderita hipertensi di usia 35th. Obat yg diberikan oleh dokter tempat sy berobat adalah adalat oros 30mg. Dan itu sdh sy konsumsi sejak bbrp thn belakangan ini. Pertanyaan sy, apakah sy dapat mengkombinasikan antara obat trsb dengan obat herbal (spt kulit manggis/bawang putih/noni)? Obat herbal apa yg cocok untuk sy disamping sy menderita hipertensi jg menderita maag. Trima kasih utk perhatiannya dok,salam.
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