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17 September 2014

[Dokter Umum] Nicotine as gateway to narcotics

 

Molecular Basis of Nicotine as a Gateway Drug

Research · September 04, 2014

TAKE-HOME MESSAGE

  • This study details the molecular mechanisms that allow nicotine to play a role as a gateway drug. The authors explain that, based on research on animal models, nicotine exerts a priming effect on cocaine through creating gene-expression environments in various areas of the brain that potentiate the effects of cocaine. The priming effect appears to occur only during simultaneous use of nicotine and cocaine, which is consistent with epidemiologic data that show most people who begin using cocaine do so during concurrent tobacco use.
  • The authors conclude that these findings suggest that smoking prevention and interventions may not only prevent negative health consequences of tobacco but also may decrease illicit drug use and addiction.

ABSTRACT                                           

Epidemiologic studies have shown that nicotine use is a gateway to the use of marijuana and cocaine in human populations. What has not been clear is how nicotine accomplishes this. In this article, we describe how our personal collaboration allowed us to bring the techniques of molecular biology to bear on this question and to reveal the action of nicotine in the brain of mice. We then apply our conclusions to the public health concerns that are being raised as the popularity of electronic cigarettes (e-cigarettes) has soared. In the process, we show the potential benefits to society of translating epidemiologic findings into public health policy.
The New England Journal of Medicine
A Molecular Basis for Nicotine as a Gateway Drug
N. Engl. J. Med 2014 Sep 04;371(10)932-943, ER Kandel, DB Kandel

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Posted by: Kartono Mohamad <mohnuh2002@yahoo.com>
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16 September 2014

[Dokter Umum] (unknown)

 

Dok saya mau bertanya
Teman saya sering kali sakit kepala dengan gejala kepala seketika dapa berpikir dengan sangat cepat dan hanya dapat disembuhkan jika berkomunikasi dengan orang lain
Jika saya boleh tau, apa nama pengakit tersebut? Karena saya mencoba konsultasi dengan dokter2 saya berkata adalah gangguan saraf tapi setelah saya baca-baca di internet, menurut saya tidak sesuai. Mohon bantuannya terima kasih

Sent from my iPhone

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Posted by: Livia Hariyanto <liviahariyanto@yahoo.com>
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09 September 2014

[Dokter Umum] FYI

 

Mudah-mudahan tidak mengenai keluarga anda

Father's smoking prior to conception could increase asthma risk for baby
European Lung Foundation News, 09/09/2014 
           
The research, presented at the European Respiratory Society (ERS) International Congress in Munich, is the first study in humans to analyse the link between a father's smoking habits before conception and a child's asthma. The findings add to growing evidence from animal studies which suggest that the father's exposures before parenthood can harm his child. The study analysed the smoking habits of over 13,000 men and women via a questionnaire. The researchers analysed the link in both mothers and fathers and looked at the number of years a person had smoked prior to conception, the incidence of asthma in children and whether the parent had quit before the baby was conceived. The results showed that non–allergic asthma (without hayfever) was significantly more common in children with a father who smoked prior to conception. This risk of asthma increased if a father smoked before the age of 15 and this risk grew the longer the duration of smoking. The researchers observed no link between the mother's smoking prior to conception and a child's asthma.

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Posted by: Kartono Mohamad <mohnuh2002@yahoo.com>
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08 September 2014

[Dokter Umum] Fw: [nasional-list] Seorang patiot sekaligus humanis sejati ! Dr. Lie --- kisah hidupnya.

 



On Tuesday, September 9, 2014 5:57 AM, "iwamardi iwamardi@yahoo.de [nasional-list]" <nasional-list@yahoogroups.com> wrote:


 
Kisah seorang patriot Indonesia sejati dan humanis besar.
Silahkan saksikan sendiri  di acara Hitam-Putih  tgl.   08.09.2014.

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Posted by: Kartono Mohamad <mohnuh2002@yahoo.com>
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02 September 2014

[Dokter Umum] Pertanyaan tentang efek game fps pada mata

 

Selamat malam dok. Saya mau tanya. Saya kan membaca artikel tentang efek positif game fps pada mata. Nah game fps tersebut kok bisa menimbulkan efek positif ? Dan bagian mata manakah yang paling banyak menerima efeknya dan kenapa kok bisa? Mohon maaf bila ada kata yang kurang berkenan. Terima kasih banyak.

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Posted by: graharjo@ymail.com
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